This study examined Uruguayan hospital admissions for acute myocardial infarction (AMI) from 37 hospitals for two years before and 2 years after implementation of a clean indoor air law. Two years after the smoke-free policy was enacted, hospital admissions for AMI fell by 22 percent. The same pattern and roughly the same magnitude of reduction in AMI admissions were also observed for patients seen in public and private hospitals, men, women, and people aged 40-65.